Background; Obesity has become a problem of public health and nutrition in the world. The prevalence of obesity is increasing in recent years and has led to serious health problems. Globally at least 2.8 million deaths each year linked to weight gain and obesity. Obesity that persist and excessive food intake can cause metabolic system disorders such as hypercholesterolemia. Conditions of excess cholesterol in the blood can cause atherosclerosis, coronary heart disease, stroke, and high blood pressure that can lead to death. Obesity is often associated with hypercholesterolemia condition, but sometimes also high cholesterol levels in people who have normal weight. Purpose: This study aimed to compare the levels of cholesterol in adults with obesity and non-obese. Method: This type of research is descriptive analytic with cross sectional design. This research was conducted in the Polytechnic Health Ministry of Medan. The study population numbered 375 sample size is determined based on inclusion criteria and taken by accidental sampling. Test data used is T test with significant level of p = 0:05. Result: The results of this study indicate that there is no difference in cholesterol levels between people who are obese with non-obese where the average cholesterol levels of obese people is 188.89 while the average cholesterol level non-obese person is 190.11. T test results showed that the value of t = 0932 which means greater than 0.05 which means that the two groups are identical (no difference).Conclusion: There is no difference in cholesterol levels between people who are obese with non-obese Keywords : Obesity, non Obesity, cholesterol