Background: The most common dental problem in the community is dental caries. Dental caries can cause toothache, it will make a person to do response called medication-seeking behavior. As many as 60% of adolescents in the Rogoitan Hamlet have caries, 40% chose to do self-medication, 10% chose to ignore their toothache, and 50% chose to go to a health care facility. Research Objective: To find out the description of dental caries and the behavior of adolescents in the Rogoitan Hamlet in looking medication for toothache. Research Method: This type of research is a descriptive research with a cross sectional design. The research population was all adolescents in Rogoitan Hamlet who had dental caries. The total sample was 66 people taken by using non probability sampling with total sampling technique. The data which were taken included dental caries and toothache medication-seeking behavior by filling out online questionnaires by adolescents in Rogoitan Hamlet, Pendowoharjo, Sewon, Bantul, Yogyakarta. The data were analyzed using cross-tabulation. Research Results: Most of the respondents had a slight dental caries with 1-2 dental caries (54.55%) and chose to self-medicate the toothache they suffered (43.94%). Male respondents chose to self-medicate their toothache (55.56%) and female respondents chose to go to modern health care facilities (43.8%). Respondents aged 12-15 (60.0%), 16-20 years (41.4%), and 21-25 years (43.8%) chose to self-medicate their toothache. Respondents of junior high school education (75.0%) and college education (45.5%) chose to self-medicate their toothache, while respondents from senior high school education chose to go to modern health care facilities (50.0%). Conclusion: Most respondents had slight dental caries and chose to looking for medication at modern health care facilities. Keywords: dental caries, medication-seeking behavior, toothache