In vitro hemocompatibility of PVA-alginate ester as a candidate for hemodialysis membrane

Choirul, Amri In vitro hemocompatibility of PVA-alginate ester as a candidate for hemodialysis membrane. International Journal of Biological Macromolecules, 82. pp. 48-53.

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Abstract

Alginate based biopolymer with improved physical and chemical properties after esterification usingpolyvinyl alcohol (PVA) has been studied for possible application as a hemodialysis membrane. Thealginic acid to vinyl alcohol molar ratio was predetermined at 0, 0.1, 0.5 and 1. Mechanical strength,hydrophilicity and Ca2+adsorption of the membrane before and after modification were evaluated. Theobtained PVA-alginate (PVA-Alg) ester membrane was also confirmed using FTIR and SEM. It showsthat the PVA-Alg membrane tensile strength is higher than that of native alginate. The water contactangle of the membrane was found to be around 33–50◦. The Ca2+adsorption capacity tends to decreasewith the increase in molar ratio. Furthermore, the modified PVA-Alg ester membrane achieves betterprotein adsorption and platelet adhesion than the unmodified one. It also exhibits a dialysis perfor-mance of 47.1–50.0% for clearance of urea and 42.2–44.6% for clearance of creatinine, respectively. It isexpected that this PVA-Alg ester may challenge cellulose acetate for potential application as hemodialysismembranes.

Item Type: Article
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
T Technology > TP Chemical technology
Divisions: > Jurusan
Depositing User: admin kesling
Date Deposited: 11 Dec 2017 04:53
Last Modified: 06 Aug 2020 06:33
URI: http://eprints.poltekkesjogja.ac.id/id/eprint/329

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