In vitro hemocompatibility of PVA-alginate ester as a candidate for hemodialysis membrane

Choirul, Amri (2016) In vitro hemocompatibility of PVA-alginate ester as a candidate for hemodialysis membrane. International Journal of Biological Macromolecules, 82. pp. 48-53.

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Abstract

Alginate based biopolymer with improved physical and chemical properties after esterification using polyvinyl alcohol (PVA) has been studied for possible application as a hemodialysis membrane. The alginic acid to vinyl alcohol molar ratio was predetermined at 0, 0.1, 0.5 and 1. Mechanical strength, hydrophilicity and Ca2+ adsorption of the membrane before and after modification were evaluated. The obtained PVA-alginate (PVA-Alg) ester membrane was also confirmed using FTIR and SEM. It shows that the PVA-Alg membrane tensile strength is higher than that of native alginate. The water contact angle of the membrane was found to be around 33–50◦. The Ca2+ adsorption capacity tends to decrease with the increase in molar ratio. Furthermore, the modified PVA-Alg ester membrane achieves better protein adsorption and platelet adhesion than the unmodified one. It also exhibits a dialysis performance of 47.1–50.0% for clearance of urea and 42.2–44.6% for clearance of creatinine, respectively. It is expected that this PVA-Alg ester may challenge cellulose acetate for potential application as hemodialysis membranes.

Item Type: Article
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
T Technology > TP Chemical technology
Divisions: > Jurusan
Depositing User: admin kesling
Date Deposited: 11 Dec 2017 06:01
Last Modified: 27 Jul 2020 05:58
URI: http://eprints.poltekkesjogja.ac.id/id/eprint/348

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