STUDY OF PREPARATION AND CHARACTERIZATION OF ESTERIFIED ALGINATE AS HEMODIALYSIS MEMBRANE

Choirul, Amri (2015) STUDY OF PREPARATION AND CHARACTERIZATION OF ESTERIFIED ALGINATE AS HEMODIALYSIS MEMBRANE. Doctoral thesis, Universitas Gadjah Mada.

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Abstract

The ability of alginate to form film and its functional group properties are interesting to be studied as candidate of hemodialysis membrane. The main weakness of alginate as a membrane are low stability in water and low mechanical strength. Moreover, the excessive of carboxylic groups of alginate enable it to trigger protein adsorption on the membrane surface. For that reasons, this study is aimed to increase stability and mechanical strength of membrane, and also to decrease the protein adsorption on the membrane surface. The strategy adopted is modification of a carboxylic group through esterification using 1–butanol, 1,4–butanediol, and polyvinyl alcohol to give different reactions such as grafting, crosslink, and polymer blend. For the purpose of such study, preparation and characterization of the esterfied alginate membranes including mechanical strength (tensile strength and elongation), water sorption and stability, the performance of dialysis membrane, and the effect of hemocompatibility (the ratio of hemolysis, protein adsorption, and platelet adhesion) has been carried out. Furthermore, hydrophilicity-hydrophobicity and porosity test of the membrane were also conducted. Finally, characters of esterified alginate were compare to those of cellulose triacetate. Results of the study showed that esterification of alginate using 1–butanol, 1,4–butanediol, and polyvinyl alcohol improves the stability and the mechanical strength of the membrane. This modification also increased hemocompatibility of the membrane from the point of view of protein adsorption. Membranes of 1,4–butanediol-esterified alginate and polyvinyl alcohol-esterified alginate membranes showed closer character of the membrane of cellulose triacetate as compared to that of 1–butanol-esterified alginate membrane. In the dialysis test for 4 hours, membrane of 1,4-butanediol-esterified alginate is able to reduce urea and creatinine of 43.8-56.8% and 38.1-50.4%, respectively, and flux of urea and creatinine of 2.61-2.75 and 0.058-0.061 mg cm-2 h-1, respectively. Meanwhile membrane of polyvinyl alcohol-esterified alginate is able to reduce urea and creatinine of 43.4-55.1% and 39.6-50.2% , respectively, and flux of urea and creatinine of 2.62-2.79 and 0.057-0.060 mg cm-2 h-1, respectively.

Item Type: Thesis (Doctoral)
Subjects: B Philosophy. Psychology. Religion > B Philosophy (General)
L Education > L Education (General)
Q Science > Q Science (General)
Q Science > QD Chemistry
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
T Technology > TJ Mechanical engineering and machinery
T Technology > TP Chemical technology
Divisions: > Jurusan
Depositing User: admin kesling
Date Deposited: 11 Dec 2017 05:42
Last Modified: 11 Dec 2017 05:42
URI: http://eprints.poltekkesjogja.ac.id/id/eprint/347

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